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Monitor Closely (1)phenobarbital will reduce the extent or effect of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl plasma concentrations, insufficient efficacy or, potentially, advancement of a wit